Abstract A007: A meta-analysis of cancer neoantigens curated from the literature
Abstract The Cancer Epitope Database and Analysis Resource (CEDAR) aggregates cancer epitope data from peer-reviewed studies, providing a structured repository of epitope-specific T cell, antibody, and MHC ligand assays. Neoantigens, arising from somatic mutations in cancer cells, represent a class of tumor-specific epitopes with potential for precision immunotherapy and as biomarkers for patient prognosis and therapeutic response. Our study harnesses CEDAR’s curated dataset to conduct a meta-analysis on neoantigens across various cancers, identifying factors contributing to neoantigen immunogenicity and their prevalence among patient populations. Citation Format: Zeynep Kosaloglu-Yalcin, Hannah Carter, Morten Nielsen, Alessandro Sette, Bjoern Peters. A meta-analysis of cancer neoantigens curated from the literature [abstract]. In: Proceedings of the AACR IO Conference: Discovery and Innovation in Cancer Immunology: Revolutionizing Treatment through Immunotherapy; 2025 Feb 23-26; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Immunol Res 2025;13(2 Suppl):Abstract nr A007.
Authors
- Alessandro Sette (ORCID: https://orcid.org/0000-0001-7013-2250)
- Bjoern Peters (ORCID: https://orcid.org/0000-0002-8457-6693)
- Zeynep Koşaloğlu (ORCID: https://orcid.org/0000-0003-0961-5055)
- Morten Nielsen (ORCID: https://orcid.org/0000-0001-7885-4311)
- Hannah Carter (ORCID: https://orcid.org/0000-0002-1729-2463)
Institutions
- La Jolla Institute for Immunology (US)
- University of California San Diego (US)
- Technical University of Denmark (DK)
Publication Details
- Journal
- Cancer Immunology Research
- Published
- 2025-02-23
- DOI
- https://doi.org/10.1158/2326-6074.io2025-a007
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00