Possible Immunomodulating Effect Ketoprofen and Ketoprofen Lysine Salt on the Brain

Abstract Ketoprofen lysine salt (KL) is a new non steroidal antiinflammatory drug (NSAID) competing with ketoprofen (K) on the market. The former is believed to have gastroprotective properies, the latter to kill acute pain. Many people drink ethanol and use NSAIDs on the days after.The aim of the study was to find out if K and KL have any immunomodulating effect on the brain after ethyl alcohol intoxication in a rat model. The experiment was carried out on 36 female Wistar rats. Animals were bred at the Experimental Medicine Centre at the Medical University of Lublin. The ethanol, NaCl, K and KL were administered by gavage. The animals were randomly divided into groups of 6.On day 7 all animals were sacrificed. Their brains and blood were collected for laboratory tests. There were no statistically significant differences in the concentration of IL-10 in the central nervous system between the study groups. We observed a positive correlation between brain IL-10 levels and body weight, also a correlation between brain IL-6 and brain weight. The level of IL-10 in the brain correlated with the concentration of IL-6 of all animals. Conclusions KL and K have some immunomodulating effect on the brain. There is a positive correlation between the level of IL-6 and IL-10 in rat brains.