Nicotinamide adenine dinucleotide rejuvenates septic bone marrow mesenchymal stem cells
Sepsis accelerates the aging of BMSCs, as evidenced by a decline in self-renewal and osteogenic capabilities, as well as weakened hematopoietic support functions. These deficiencies can be effectively reversed <i>via</i> the NAD/SIRT3/superoxide dismutase pathway.
Authors
- Zhigang Zhou (ORCID: https://orcid.org/0000-0001-6159-7793)
- Tong Yin (ORCID: https://orcid.org/0009-0009-1343-985X)
- Jinyan Zhao (ORCID: https://orcid.org/0000-0001-9771-4656)
- Kun Zhou (ORCID: https://orcid.org/0000-0002-0222-0301)
- Min Zhao (ORCID: https://orcid.org/0000-0002-7154-8415)
- Xin Xia (ORCID: https://orcid.org/0009-0000-3101-2555)
- Brian Tian
- Lin-Ying An (ORCID: https://orcid.org/0000-0003-0903-3354)
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai First People's Hospital (CN)
Publication Details
- Journal
- World Journal of Stem Cells
- Published
- 2025-02-24
- DOI
- https://doi.org/10.4252/wjsc.v17.i2.96893
- Citations
- 3
- Primary Topic
- PARP inhibition in cancer therapy
- Type
- article
- Field-Weighted Citation Impact
- 3.14