Identification of small fiber neuropathy in neuronal intranuclear inclusion disease: A clinicopathological study
Our study is the first to identify wide and severe non-length dependent small fiber neuropathy in neuronal intranuclear inclusion disease (NIID) patients. Approximately 50% of NIID patients exhibited pure small fiber neuropathy without large fiber or mixed neuropathy. NIID patients showed a significant reduction in noradrenergic, cholinergic, peptidergic, and regenerative fiber innervation. Small fiber densities, especially intraepidermal nerve fiber density, demonstrated high diagnostic accuracy in distinguishing NIID patients from healthy controls and other disease groups. Findings suggest that small fiber neuropathy may play a role in the pathogenesis of NIID.
Authors
- Lanjun Li (ORCID: https://orcid.org/0000-0001-7660-3500)
- Jing Yang (ORCID: https://orcid.org/0000-0002-7356-5083)
- R. Liu (ORCID: https://orcid.org/0000-0003-0853-9863)
- Yanpeng Yuan
- C. Liu (ORCID: https://orcid.org/0000-0001-5451-8305)
- Yuming Xu (ORCID: https://orcid.org/0000-0003-2689-9897)
- Yan‐Jiang Wang (ORCID: https://orcid.org/0000-0002-6227-6112)
- Ting Yang (ORCID: https://orcid.org/0000-0002-5204-2347)
- Yue-Qiang Xue
- Minglei Liu (ORCID: https://orcid.org/0000-0002-6722-1305)
- Yangyang Wang (ORCID: https://orcid.org/0000-0001-7042-9804)
- Han Liu (ORCID: https://orcid.org/0000-0002-0014-4675)
- Yanlin Wang (ORCID: https://orcid.org/0000-0002-6908-1529)
- Shuo Li (ORCID: https://orcid.org/0000-0003-2331-2448)
- Lin Cheng (ORCID: https://orcid.org/0000-0003-3825-5378)
- Xiaojing Liu (ORCID: https://orcid.org/0000-0002-4632-310X)
- Yuan Gao (ORCID: https://orcid.org/0000-0003-2596-4773)
- Ke Zhang (ORCID: https://orcid.org/0000-0001-6777-6290)
- Tianyuan Yang (ORCID: https://orcid.org/0000-0003-4219-837X)
- Ying Kong (ORCID: https://orcid.org/0000-0002-3782-1246)
- Jing Yuan (ORCID: https://orcid.org/0009-0003-3463-2030)
Institutions
- Army Medical University (CN)
- Daping Hospital (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/alz.14596
- Citations
- 5
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 6.95
Funders
- National Natural Science Foundation of China
- Zhengzhou University
- Chinese Academy of Medical Sciences
- First Affiliated Hospital of Zhengzhou University