Transposable elements may enhance antiviral resistance in HIV-1 elite controllers
We propose that the EC phenotype is driven in part by reduced KZNF-mediated repression of specific TE-derived cis-regulatory elements for antiviral genes, heightening their resistance against HIV-1. Our study reveals heterogeneity in the EC CD4<sup>+</sup> T cell transcriptome, including variable expression of TEs and their KZNF controllers, that must be considered when deciphering HIV-1 control mechanisms.
Authors
- Sabrina M. Leddy (ORCID: https://orcid.org/0000-0002-5104-3866)
- L. Iñiguez (ORCID: https://orcid.org/0000-0002-1470-9024)
- Douglas F. Nixon (ORCID: https://orcid.org/0000-0002-2801-1786)
- Matthew L. Bendall (ORCID: https://orcid.org/0000-0001-9816-5425)
- Cédric Feschotte (ORCID: https://orcid.org/0000-0002-8772-6976)
- Manvendra Singh (ORCID: https://orcid.org/0000-0002-8626-5418)
Institutions
- Feinstein Institute for Medical Research (US)
- Cornell University (US)
- Centre for Genomic Regulation (ES)
- Weill Cornell Medicine (US)
- Max Planck Institute for Multidisciplinary Sciences (DE)
Publication Details
- Journal
- Genome biology
- Published
- 2025-02-23
- DOI
- https://doi.org/10.1186/s13059-025-03484-y
- Citations
- 9
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 9.33
Funders
- National Institutes of Health
- Weill Cornell Medical College