Population Pharmacokinetics of Cefepime in Critically Ill Children and Young Adults: Model Development and External Validation for Monte Carlo Simulations and Model-Informed Precision Dosing
A cefepime population pharmacokinetic model for critically ill pediatric patients was successfully developed, accounting for patient renal function, fluid status, and body size, using real-world data. The model was internally and externally validated for use in optimal dosing simulations and model-informed precision dosing.
Authors
- Abigayle Gibson
- Tomoyuki Mizuno (ORCID: https://orcid.org/0000-0002-8471-9826)
- Michaela Collins
- Horace Rhodes Hambrick (ORCID: https://orcid.org/0000-0003-1218-8293)
- Kelli Paice (ORCID: https://orcid.org/0000-0003-0863-7316)
- Peter Torben Tang (ORCID: https://orcid.org/0000-0003-4419-3046)
- Sonya Tang Girdwood (ORCID: https://orcid.org/0000-0001-7737-8499)
- Erin E. Schuler
- Jennifer Kaplan (ORCID: https://orcid.org/0000-0001-7020-2394)
- Kathryn Pavia (ORCID: https://orcid.org/0000-0002-6231-3323)
- Luana Johnson
- Stuart Goldstein
- Kelli A. Krallman (ORCID: https://orcid.org/0000-0002-3275-2982)
- Ronaldo Morales (ORCID: https://orcid.org/0000-0002-5856-3717)
- Calise Curry
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- Clinical Pharmacokinetics
- Published
- 2025-02-23
- DOI
- https://doi.org/10.1007/s40262-025-01485-5
- Citations
- 3
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- National Institutes of Health
- National Institute of General Medical Sciences
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development