Autoimmune Rhombencephalitis as a Presentation of Post-COVID-19 Syndrome: A Case Report

There has been a multitude of neurological sequelae associated with the 2019 SARS-CoV-2 outbreak. We describe a unique case of a 31-year-old individual who developed post-infectious autoimmune rhombencephalitis approximately two weeks after testing positive for coronavirus disease 2019 (COVID-19). Treatment with high-dose corticosteroids with four weeks of taper resulted in excellent clinical recovery without any relapse. Thus, our findings support the use of immunotherapy as a potential treatment in cases of post-COVID-19 autoimmune rhombencephalitis. Furthermore, this case highlights the importance of considering post-infectious COVID-19 sequelae as a differential diagnosis in patients presenting with rhombencephalitis in the appropriate clinical setting.

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Publication Details

Journal
Cureus
Published
2025-02-23
DOI
https://doi.org/10.7759/cureus.79517
Primary Topic
Long-Term Effects of COVID-19
Type
article
Field-Weighted Citation Impact
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article

Autoimmune Rhombencephalitis as a Presentation of Post-COVID-19 Syndrome: A Case Report

Askiel Bruno, Alaa S. Mohamed, Manan Shah, Dilip Singh et al.
Cureus
Long-Term Effects of COVID-19
article

Autoimmune Rhombencephalitis as a Presentation of Post-COVID-19 Syndrome: A Case Report

Askiel Bruno, Alaa S. Mohamed, Manan Shah, Dilip Singh, Neesha Jahani, Mingyu Li
article en

Abstract

There has been a multitude of neurological sequelae associated with the 2019 SARS-CoV-2 outbreak. We describe a unique case of a 31-year-old individual who developed post-infectious autoimmune rhombencephalitis approximately two weeks after testing positive for coronavirus disease 2019 (COVID-19). Treatment with high-dose corticosteroids with four weeks of taper resulted in excellent clinical recovery without any relapse. Thus, our findings support the use of immunotherapy as a potential treatment in cases of post-COVID-19 autoimmune rhombencephalitis. Furthermore, this case highlights the importance of considering post-infectious COVID-19 sequelae as a differential diagnosis in patients presenting with rhombencephalitis in the appropriate clinical setting.

CureusVol. 17(2)
Augusta University (US)
Good health and well-being
Openalex Percentile: Top 94%
Long-Term Effects of COVID-19
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