Responses of B-type natriuretic peptide (BNP), mature BNP and proBNP to sacubitril/valsartan differs between responders and non-responders
These results suggest that the magnitude and direction of change in each BNP form depends on its substrate specificity for neprilysin, that differences in plasma levels of each BNP form between responders and non-responders appear early and persist and that BNPcom levels at 4 weeks can be applicable to prediction of the responders. Notably, our findings show that the idea that BNPcom cannot be used as a marker of heart failure after sacubitril/valsartan should be reconsidered.
Authors
- Koh Ono (ORCID: https://orcid.org/0000-0002-4163-980X)
- Kenji Moriuchi (ORCID: https://orcid.org/0000-0002-5826-0791)
- Yasuaki Nakagawa (ORCID: https://orcid.org/0000-0002-5664-963X)
- Shoichi Miyamoto
- Naoto Minamino (ORCID: https://orcid.org/0000-0002-9913-1144)
- Toshio Nishikimi (ORCID: https://orcid.org/0000-0001-8595-3780)
- Yusuke Tamamura
- Takahiko Kanamori
- Hiroyuki Takahama (ORCID: https://orcid.org/0000-0002-4868-0901)
- Hiromu Yanagisawa (ORCID: https://orcid.org/0000-0002-5147-9360)
- Hideaki Kinoshita
- Hideaki Inazumi
Institutions
- Tohoku University (JP)
- Kyoto University (JP)
- National Cerebral and Cardiovascular Center (JP)
- Sumitomo Hospital (JP)
- Hyogo Prefectural Nishinomiya Hospital (JP)
- Wakaba Hospital (JP)
- Kitano Hospital (JP)
Publication Details
- Journal
- Open Heart
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1136/openhrt-2024-002990
- Citations
- 2
- Primary Topic
- Heart Failure Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- Japan Society for the Promotion of Science