Two new tetralones from the endophytic fungus <i>Annulohypoxylon stygium</i> A888
Two new tetralones, annulohyporins A (<b>1</b>) and B (<b>2</b>), along with thirteen known compounds (<b>3</b>-<b>15</b>), were isolated from the ethyl acetate extract of solid fermentation of the endophytic fungus <i>Annulohypoxylon stygium</i> A888, which was isolated from the medicinal plant <i>Aquilaria sinensis</i>. The structures of annulohyporins A and B were established by detailed analyses of ultraviolet-visible spectroscopy (UV), infrared spectroscopy (IR), mass spectrometry (MS), electronic circular dichroism (ECD) calculations and nuclear magnetic resonance (NMR). Bioactivity assay showed that compounds <b>3</b> and <b>4</b> had significant α-glucosidase inhibitory activities with IC<sub>50</sub> values of 64.00 and 32.90 µM, respectively.
Authors
- Yuchan Chen
- Hongxin Liu (ORCID: https://orcid.org/0000-0001-7590-6956)
- Saini Li
- Weimin Zhang (ORCID: https://orcid.org/0000-0001-8945-9448)
- Xiaoying Chen (ORCID: https://orcid.org/0000-0002-6710-3798)
- Weipeng Ma
- Zhishen Shao
Institutions
- Guangdong Pharmaceutical University (CN)
- Dongguan University of Technology (CN)
- Guangdong Academy of Sciences (CN)
- Institute of Microbiology (CN)
Publication Details
- Journal
- Journal of Asian Natural Products Research
- Published
- 2025-02-22
- DOI
- https://doi.org/10.1080/10286020.2025.2464683
- Citations
- 2
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University