Mucin 4 expression is associated with metastasis in triple-negative breast cancer and can be tackled by soluble TNF blockade, improving immunotherapy outcome
We proved the existence of a sTNF/MUC4 axis in TNBC that can be actionable by sTNF neutralization, preventing metastasis. We suggest that MUC4 is a suitable biomarker to guide immunotherapy in TNBC, together with the administration of sTNF blocking drugs to improve outcome.
Authors
- Rosalía I. Cordo Russo (ORCID: https://orcid.org/0000-0002-5984-9717)
- Daniel Lopez Della Vecchia
- Elmer A. Fernández (ORCID: https://orcid.org/0000-0002-4711-8634)
- Alejandro J. Urtreger (ORCID: https://orcid.org/0000-0002-2338-7821)
- Sofía Bruni (ORCID: https://orcid.org/0000-0001-7429-8039)
- Silvina Figurelli
- Ernesto Gil Deza
- Sabrina Barchuk
- María F. Mercogliano (ORCID: https://orcid.org/0000-0003-1094-9247)
- Agustina Dupont
- Florencia Mauro
- Roxana Schillaci (ORCID: https://orcid.org/0000-0002-7776-3378)
- A Nava (ORCID: https://orcid.org/0000-0002-5383-1380)
- Gloria Inurrigarro
- Yanina Rivenson
- Aldana Schey
- Agustina Badalini
Institutions
- Universidad Nacional de Córdoba (AR)
- Universidad de Buenos Aires (AR)
- Mater Dei Hospital (MT)
- Hospital Fernández (AR)
- Instituto Oncológico Henry Moore (AR)
- Sanatorio Otamendi y Miroli (AR)
- Experimental Medicine and Biology Institute (AR)
Publication Details
- Journal
- Translational Oncology
- Published
- 2025-02-22
- DOI
- https://doi.org/10.1016/j.tranon.2025.102325
- Citations
- 2
- Primary Topic
- Glycosylation and Glycoproteins Research
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Agencia Nacional de Promoción Científica y Tecnológica