Synergistic effects of memantine and alpha7 nicotinic acetylcholine receptor agonist PHA-543613 to improve memory of aged rats
Results indicate a positive interaction between memantine and PHA-543613, which also reflects a putative role of α7 nAChRs in the cognitive enhancer effects of memantine. These findings may facilitate the development of combination therapies for age-related neurocognitive disorders.
Authors
- Zsolt Kristóf Bali (ORCID: https://orcid.org/0000-0003-0712-0788)
- Péter Engelmann (ORCID: https://orcid.org/0000-0002-9284-4985)
- Kornélia Bodó (ORCID: https://orcid.org/0000-0001-9429-4377)
- Nóra Bruszt
- Lili Veronika Nagy (ORCID: https://orcid.org/0000-0001-7019-4363)
- István Hernádi (ORCID: https://orcid.org/0000-0001-7882-4817)
Institutions
- Institut des Sciences Cognitives Marc Jeannerod (FR)
- Czech Academy of Sciences, Institute of Physiology (CZ)
- University of Pecs (HU)
Publication Details
- Journal
- The International Journal of Neuropsychopharmacology
- Published
- 2025-02-22
- DOI
- https://doi.org/10.1093/ijnp/pyaf014
- Citations
- 2
- Primary Topic
- Nicotinic Acetylcholine Receptors Study
- Type
- article
- Field-Weighted Citation Impact
- 1.61