CORRELATION BETWEEN HIGH SENSITIVITY C-REACTIVE PROTEIN AND GLYCOSYLATED HAEMOGLOBIN IN DIABETICS, PREDIABETICS AND NONDIABETICS.

Background- Estimation and association of high-sensitivity C-reactive protein (hs-CRP) and glycated haemoglobin (HbA1c) in diabetic patients has been studied extensively. The objectives were to estimate and correlate hs-CRPwith HbA1c and also to correlate hs-CRPand HbA1c with body mass index (BMI) and waist-hip ratio(WHR) in diabetic, pre-diabetic and non-diabetic group. Methodology- The cross sectional comparative study was done on 93 patients of which 30 were known diabetic, 33 prediabetic patients with family history of diabetes mellitus, obesity and hypertension and 30 non-diabetic patients without family history of diabetes mellitus, obesity and hypertension. Anthropometric measurements were taken and body mass index (BMI) and waist hip ratio(WHR) were calculated. Levels of serum highly sensitive C reactive protein (hs-CRP) and glycated haemoglobin (HbA1c) were estimated in all the groups. Results- Although statistically insignificant, mean BMI and hs-CRP were higher in pre-diabetic group and WHR was higher in diabetic group (P>0.05). Mean HbA1c was significantly high in diabetic (P<0.01). Significant positive correlation was found between hs-CRP and HbA1c in prediabetic groups (r=0.3545; p=0.0429). BMI was significantly correlated with HbA1c in diabetics and pre-diabetics (r=-0.408, P=0.025; r=0.452, P=0.008 respectively). Conclusion- Risk of developing T2DM in near future can be predicted by estimating hs-CRP and BMI of an individual. However, estimation of WHR and HbA1c can contribute significantly in glycemic management to avoid the further complications among diabetic patients.