Camel milk exosomes regulate glucose metabolism by inhibiting mitochondrial complex I in hepatocytes
By inhibiting the activity of mitochondrial complex I in hepatocytes, CM-exo inhibited oxidative phosphorylation, oxidation of NADH to NAD<sup>+</sup> and synthesis of ATP, enhanced glycolysis, activated AMPK and resulted in decreased gluconeogenesis and increased glycogen synthesis.
Authors
- Shihao Du
- Demtu Er (ORCID: https://orcid.org/0000-0002-5705-665X)
- Ling Liu (ORCID: https://orcid.org/0000-0002-8984-9224)
- Jingjing Wang (ORCID: https://orcid.org/0000-0002-6093-9074)
- Bin Yang (ORCID: https://orcid.org/0000-0001-8761-5670)
Institutions
- Inner Mongolia Agricultural University (CN)
Publication Details
- Journal
- BMC Veterinary Research
- Published
- 2025-02-22
- DOI
- https://doi.org/10.1186/s12917-025-04555-9
- Citations
- 1
- Primary Topic
- Animal Diversity and Health Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.16