Feasibility and comparison of 3D modified rosette ultra-short echo time (PETALUTE) with conventional weighted acquisition in 31P-MRSI
Phosphorus-31 magnetic resonance spectroscopic imaging (<sup>31</sup>P-MRSI) provides valuable non-invasivein vivoinformation on tissue metabolism but is burdened by poor sensitivity and prolonged scan duration. Ultra-short echo time (UTE) acquisitions minimize signal loss when probing signals with relatively short spin-spin relaxation time (T<sub>2</sub>), while also preventing first-order dephasing. Here, a three-dimensional (3D) UTE sequence with a rosette k-space trajectory (PETALUTE) is applied to <sup>31</sup>P-MRSI at 3T. Conventional weighted MRSI employs highly regular Cartesian k-space sampling, susceptible to substantial artifacts when accelerated via undersampling. In contrast, this novel sequence's "petal-like" pattern offers incoherent sampling more suitable for compressed sensing (CS). These results showcase the competitive performance of PETALUTE against conventional weighted <sup>31</sup>P-MRSI with simulation, phantom, and in vivo leg muscle comparisons.
Authors
- Uzay E. Emir (ORCID: https://orcid.org/0000-0001-5376-0431)
- Xin Shen (ORCID: https://orcid.org/0000-0003-0184-8751)
- Mark Chiew (ORCID: https://orcid.org/0000-0001-6272-8783)
- William T. Clarke (ORCID: https://orcid.org/0000-0001-7159-7025)
- Stephen J. Sawiak (ORCID: https://orcid.org/0000-0003-4210-9816)
- Ulrike Dydak (ORCID: https://orcid.org/0000-0003-1852-7110)
- Ali Çağlar Özen (ORCID: https://orcid.org/0000-0003-3536-0826)
- Brian Bozymski
- M. Albert Thomas
Institutions
- University of North Carolina at Chapel Hill (US)
- University of Freiburg (DE)
- University of California, Los Angeles (US)
- University of California, San Francisco (US)
- University of Toronto (CA)
- Purdue University West Lafayette (US)
- University of Cambridge (GB)
- University Medical Center Freiburg (DE)
- University of California System (US)
- University of Oxford (GB)
- Wellcome Centre for Integrative Neuroimaging (GB)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Scientific Reports
- Published
- 2025-02-22
- DOI
- https://doi.org/10.1038/s41598-025-90630-y
- Citations
- 3
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 4.08
Funders
- Indiana Clinical and Translational Sciences Institute
- Wellcome Trust
- National Institutes of Health
- National Center for Advancing Translational Sciences