Comparison of Molecular Testing Methodologies for CIC-Rearranged Sarcomas
Awareness of molecular testing pitfalls in the appropriate detection of CIC rearrangement is critical. Any CIC FISH result may need to be further confirmed, either with unequivocal immunohistochemical support or by another molecular method. A positive RNA-seq or methylation array analysis result may be sufficient evidence for a diagnosis of CIC-RS in the appropriate histologic context. A negative or inconclusive/unclassified RNA-seq or methylation array analysis result in a tumor with high initial suspicion for CIC-RS likely requires careful reevaluation.
Authors
- Jennifer Neary (ORCID: https://orcid.org/0000-0002-0036-6067)
- David A. Wheeler (ORCID: https://orcid.org/0000-0002-9056-6299)
- Maria Cardenas (ORCID: https://orcid.org/0000-0002-8183-9785)
- Zonggao Shi (ORCID: https://orcid.org/0000-0001-7503-2953)
- Selene C. Koo (ORCID: https://orcid.org/0000-0001-8459-2469)
- Larissa V. Furtado (ORCID: https://orcid.org/0000-0001-7784-9502)
- Patricia Stow
Institutions
- St. Jude Children's Research Hospital (US)
Publication Details
- Journal
- Archives of Pathology & Laboratory Medicine
- Published
- 2025-02-22
- DOI
- https://doi.org/10.5858/arpa.2024-0407-oa
- Citations
- 2
- Primary Topic
- Protein Degradation and Inhibitors
- Type
- article
- Field-Weighted Citation Impact
- 1.61