Functional Ultrasound Imaging Reveals Activation Properties of Clinical Spinal Cord Stimulation Therapy Programming

This work demonstrates that fUS can effectively measure SCS neural response patterns in the pain processing laminae of a large animal model implanted with a clinical SCS system. Hemodynamic responses in the SC varied significantly across SCS therapy modes, with multiphase stimulation providing a greater area of coverage and depth of response versus other common stimulation types.