Allicin alleviates traumatic brain injury-induced neuroinflammation by enhancing PKC-δ-mediated mitophagy
This study uncovers a novel mechanism where allicin enhances PKC-δ expression and PLS3 phosphorylation, facilitating CL translocation to the OMM and activating mitophagy, thereby reducing TBI-induced neuroinflammation.
Authors
- Yangfan Ye
- Zhongyuan Bao
- Xiaoyan Wu (ORCID: https://orcid.org/0000-0002-9708-6060)
- Yue Cheng (ORCID: https://orcid.org/0000-0003-4638-5674)
- Honglu Chao
- Wei Tian (ORCID: https://orcid.org/0000-0002-8214-5347)
- Wei Gu (ORCID: https://orcid.org/0000-0001-5908-1616)
- Z M Mu
Institutions
- Wuxi No.2 People's Hospital (CN)
- Jiangsu Province Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-02-22
- DOI
- https://doi.org/10.1016/j.phymed.2025.156500
- Citations
- 15
- Primary Topic
- Garlic and Onion Studies
- Type
- article
- Field-Weighted Citation Impact
- 26.25
Funders
- Natural Science Foundation of Jiangsu Province