In Silico Interim Adaptation of Proton Therapy in Head and Neck Cancer by Simultaneous Dose and Linear Energy Transfer Escalation
Our in silico study showed that dose-LET escalation in proton therapy integrating a variable-RBE model may improve proton therapy for patients with HNC. Clinical evaluation of such a biological image-based dose-LET escalation in proton therapy of HNC remains to be investigated.
Authors
- Mirjam Delange Alsaker
- Kristian S. Ytre-Hauge (ORCID: https://orcid.org/0000-0002-3597-1611)
- Helge Henjum (ORCID: https://orcid.org/0000-0002-0142-8864)
- Guillermo Garrido-Hernandez (ORCID: https://orcid.org/0000-0002-4986-0154)
- René M. Winter (ORCID: https://orcid.org/0000-0001-7282-6846)
- Signe Danielsen
- Kathrine Røe Redalen (ORCID: https://orcid.org/0000-0002-1172-4632)
Institutions
- Norwegian University of Science and Technology (NO)
- St Olav's University Hospital (NO)
- University of Bergen (NO)
Publication Details
- Journal
- International Journal of Radiation Oncology*Biology*Physics
- Published
- 2025-02-22
- DOI
- https://doi.org/10.1016/j.ijrobp.2025.02.015
- Citations
- 3
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 4.56
Funders
- Trond Mohn stiftelse
- Norges Forskningsråd