Pd-IPent-Catalyzed Defluorinative Annulation of <i>gem</i>-Difluorocyclopropanes with Enamides: Synthesis of Multisubstituted <i>N</i>-H Pyrroles
We present a Pd-IPent-catalyzed ring-opening defluorinative annulation reaction of <i>gem</i>-difluorocyclopropanes with enamides, which provides a convenient and efficient strategy for the synthesis of multisubstituted <i>N</i>-H pyrrole derivatives. This transformation selectively cleaves the C<sub>1</sub>-C<sub>3</sub> bond, two C-F bonds, and the C-N bond in a one-pot procedure. Additionally, this protocol allows for the modification of several bioactive molecules.
Authors
- Leiyang Lv (ORCID: https://orcid.org/0000-0002-2850-8952)
- Jiping Sheng (ORCID: https://orcid.org/0000-0003-1259-6350)
- Wenhao Liu (ORCID: https://orcid.org/0000-0001-9757-1077)
- Zhiping Li (ORCID: https://orcid.org/0000-0001-7987-279X)
- Yahui Ma
- Qiuwei Huang
Institutions
- Renmin University of China (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1021/acs.orglett.5c00241
- Citations
- 7
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 5.54
Funders
- National Natural Science Foundation of China
- Renmin University of China
- Beijing Municipal Natural Science Foundation
- Fundamental Research Funds for the Central Universities