Cu_2–<i>x</i>O@Ti₃C₂ Integrated Photothermal Nanofibers with Antibacterial, Anti-Inflammatory, and Hemostatic Properties for Promoting Infected Diabetic Wound Healing

Infected diabetic wounds represent a significant challenge in clinical care due to persistent inflammation and impaired healing. To address these issues, the development of novel wound dressings with both antibacterial and reactive oxygen species (ROS) scavenging properties is essential. Herein, we prepare a novel wound dressing composed of Cu_2-<i>x</i>O nanoparticles decorated on Ti₃C₂ MXene (Cu_2-<i>x</i>O@Ti₃C₂) and integrate it into a poly(vinyl alcohol) (PVA) matrix to form electrospun nanofibers (Cu_2-<i>x</i>O@Ti₃C₂@PVA). Cu_2-<i>x</i>O@Ti₃C₂ exhibits remarkable photothermal conversion efficiency and effective ROS scavenging properties. In vitro experiments demonstrated that Cu_2-<i>x</i>O@Ti₃C₂ effectively kills bacteria upon near-infrared (NIR) irradiation, which can be attributed to the photothermal therapy (PTT) effect of Ti₃C₂. At the same time, the ROS scavenging abilities of both Ti₃C₂ and Cu_2-<i>x</i>O endow Cu_2-<i>x</i>O@Ti₃C₂ with significant in vitro anti-inflammatory effects. As a promising wound dressing, in vivo studies validated the high efficacy of Cu_2-<i>x</i>O@Ti₃C₂@PVA in promoting hemostasis, exerting antibacterial activity, reducing inflammation, and accelerating the healing process of diabetic wounds. This innovative approach provides a comprehensive solution to the multifaceted challenges of diabetic wound healing and paves the way for improved clinical outcomes.