Smilax glabra roxb. alleviates cisplatin-induced acute kidney injury in mice by activating the Nrf2/HO-1 Signalling Pathway
In both in vivo and in vitro experiments, TFL activated the Nrf2/HO-1 signalling pathway, promoting the expression of antioxidant enzymes and thereby ameliorating CDDP-induced oxidative stress, mitochondrial dysfunction and renal cell apoptosis.
Authors
- Gang Yin (ORCID: https://orcid.org/0000-0002-0839-242X)
- Hongyue Ma (ORCID: https://orcid.org/0000-0002-0987-8317)
- Gang Wang
- Zengyaran Yue
- Lin Zhao (ORCID: https://orcid.org/0000-0003-2994-2387)
- Decai Tang
- Jiahui Qin
Institutions
- Nanjing University of Chinese Medicine (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-02-22
- DOI
- https://doi.org/10.1016/j.phymed.2025.156550
- Citations
- 7
- Primary Topic
- Chemotherapy-induced organ toxicity mitigation
- Type
- article
- Field-Weighted Citation Impact
- 10.30
Funders
- National Natural Science Foundation of China