Integrating transcriptomics and scPagwas analysis predicts naïve CD4 T cell-related gene DRAM2 as a potential biomarker and therapeutic target for colorectal cancer
The DRAM2 gene, associated with CD4Tn cells, appears to play a pivotal role in the advancement of CRC and may represent a promising therapeutic target for treatment.
Authors
- Tiankuo Luan
- Benhua Li
- Jiaming He (ORCID: https://orcid.org/0000-0003-2912-4667)
- Jian Yue (ORCID: https://orcid.org/0009-0009-9868-0959)
- Xiaofang Li (ORCID: https://orcid.org/0000-0002-0604-849X)
- Rui Feng (ORCID: https://orcid.org/0000-0001-5283-3803)
- Guojing Liu
Institutions
- Affiliated Hospital of Southwest Medical University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Xian Yang Central Hospital (CN)
- Gaozhou People's Hospital (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1186/s12885-025-13731-x
- Citations
- 2
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 2.09