Excess of rare noncoding variants in several type 2 diabetes candidate genes among Asian Indian families
The high burden of T2D in these families may stem from the enrichment of noncoding RVs in a small number of major known genes (including MODY genes) with oligogenic inheritance alongside RVs from genes associated with polygenic susceptibility. These findings highlight the need to conduct deeper evaluations of families from non-European ancestries to identify potential novel therapeutics and implement preventative strategies.
Authors
- John Blangero (ORCID: https://orcid.org/0000-0001-6250-5723)
- Deepika Ramu (ORCID: https://orcid.org/0000-0003-0580-5492)
- Dharambir K. Sanghera (ORCID: https://orcid.org/0000-0001-7203-8655)
- Teena Koshy
- Juan Carlos López-Alvarenga (ORCID: https://orcid.org/0000-0002-0966-8766)
- Umarani Ravichandran
- Sadagopan Thanikachalam
- Srinivas Mummidi (ORCID: https://orcid.org/0000-0002-4068-6380)
- Marcio Almeida (ORCID: https://orcid.org/0000-0002-8114-3892)
- R Parthasarathy
- Juliet A. Ezeilo
- Gurpreet Singh Wander (ORCID: https://orcid.org/0000-0002-4596-4247)
- Piers R. Blackett (ORCID: https://orcid.org/0000-0002-2320-1134)
- Christopher E. Aston (ORCID: https://orcid.org/0000-0002-5682-715X)
- Mahaboob Vali Shaik (ORCID: https://orcid.org/0000-0003-4059-1709)
- Ravindranath Duggirala (ORCID: https://orcid.org/0000-0003-4761-597X)
- Roy G. Resendez
- Krishna Mohan Medicherla
- Thyagarajan Sadras Panchatcharam
- Solomon F.D. Paul (ORCID: https://orcid.org/0000-0002-0829-7780)
- Priyanka Venugopal (ORCID: https://orcid.org/0000-0003-1830-4419)
- Sailesh Lodha
- Dileep Kumar K
- Madhusmita Rout
- S. NOELTA
- Rajeev Gupta (ORCID: https://orcid.org/0000-0002-8356-3137)
- Natesan Chidambaram
- Vettriselvi Venkatesan (ORCID: https://orcid.org/0000-0003-2827-8680)
- Rector Arya (ORCID: https://orcid.org/0000-0001-7372-5043)
- Krishna Kumar Sharma
- Asish K. Ghosh (ORCID: https://orcid.org/0000-0002-4087-738X)
- Surendra K. Sharma (ORCID: https://orcid.org/0000-0003-1128-1672)
- N. K. Mehra
- Sarju Ralhan
- Jai Rup Singh
- Amaresh Reddy Ponnala
- Juan Paralta
- Mendez Mariana
Institutions
- Texas A&M University – San Antonio (US)
- Guru Nanak Dev University (IN)
- Annamalai University (IN)
- Sri Ramachandra Institute of Higher Education and Research (IN)
- The University of Texas Rio Grande Valley (US)
- Rajasthan University of Health Sciences (IN)
- Dayanand Medical College & Hospital (IN)
- Krishna Institute of Medical Sciences (IN)
- Narayana Dental College and Hospital (IN)
- Birla Institute of Scientific Research (IN)
- Eternal Hospital (IN)
- University of Oklahoma Health Sciences Center (US)
- All India Institute of Medical Sciences (IN)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-02-22
- DOI
- https://doi.org/10.1038/s43856-025-00750-9
- Citations
- 2
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 3.63
Funders
- Foundation for the National Institutes of Health
- Presbyterian Health Foundation
- Indian Council of Medical Research
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases