Genetic diversity and dietary adaptations of the Central Plains Han Chinese population in East Asia
The Central Plains Han Chinese (CPHC) is the typical agricultural population of East Asia. Investigating the genome of the CPHC is crucial to understanding the genetic structure and adaptation of the modern humans in East Asia. Here, we perform whole genome sequencing of 492 CPHC individuals and obtained 22.65 million SNPs, 4.26 million INDELs and 41,959 SVs. We found the CPHC has a higher level of genetic diversity and the glycolipid metabolic genes show strong selection signals, e.g. LONP2, FADS2, FGF21 and SLC19A2. Ancient DNA analyses suggest that the domestication of crops, which drove the emergence of the candidate mutations. Notably, East Asian-specific SVs, e.g., DEL_21699 (LINC01749) and DEL_38406 (FAM102A) may be associated with the high prevalence of esophageal squamous carcinoma and primary angle-closure glaucoma. Our results provide an important genetic resource and show that dietary adaptations play an important role in phenotypic evolution in East Asian populations.
Authors
- Y. Guo (ORCID: https://orcid.org/0000-0003-4588-1713)
- Chuan‐Chao Wang (ORCID: https://orcid.org/0000-0001-9628-0307)
- Bing Su (ORCID: https://orcid.org/0000-0002-4379-9014)
- Zhaohui Yang (ORCID: https://orcid.org/0000-0003-0958-4439)
- Xin Hou (ORCID: https://orcid.org/0000-0002-3705-0736)
- Zhongmin Qiu (ORCID: https://orcid.org/0000-0002-6612-7413)
- Peng Lei (ORCID: https://orcid.org/0000-0001-7422-0258)
- Xiaoyu Xu (ORCID: https://orcid.org/0000-0002-0327-7369)
- Wangshan Zheng (ORCID: https://orcid.org/0000-0002-6174-4746)
- Wenxue Tang (ORCID: https://orcid.org/0000-0001-8087-0900)
- Youwei Pu (ORCID: https://orcid.org/0000-0001-8163-976X)
- Hongen Xu (ORCID: https://orcid.org/0000-0001-7895-0899)
- Jianxiang Shi (ORCID: https://orcid.org/0000-0002-4346-3895)
- Xiangqian Guo (ORCID: https://orcid.org/0000-0001-6645-5786)
- Yaoxi He (ORCID: https://orcid.org/0000-0003-3324-3239)
- Habtom K. Bitsue
- Xinwei Wang (ORCID: https://orcid.org/0000-0001-6057-8400)
- Kai Liu (ORCID: https://orcid.org/0000-0001-9351-1640)
- Shanshan Wang (ORCID: https://orcid.org/0000-0001-6373-8908)
- Jingru Zhao (ORCID: https://orcid.org/0000-0003-1184-2775)
- Hao Ma (ORCID: https://orcid.org/0000-0001-7874-0752)
- Jiancheng Guo (ORCID: https://orcid.org/0000-0001-8553-4105)
- Xiaoyang Qiao
- Xia Xue
Institutions
- Henan University (CN)
- Kunming Institute of Zoology (CN)
- Xiamen University (CN)
- Chinese Academy of Sciences (CN)
- Zhengzhou University (CN)
- Second Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Communications Biology
- Published
- 2025-02-22
- DOI
- https://doi.org/10.1038/s42003-025-07760-2
- Citations
- 2
- Primary Topic
- Nutrition, Genetics, and Disease
- Type
- article
- Field-Weighted Citation Impact
- 3.63
Funders
- National Natural Science Foundation of China
- Zhengzhou University
- National Supercomputing Center, Korea Institute of Science and Technology Information