Copper-catalyzed sulfonylation of alkenes with CH3SSO3Na
A successful methodology for the copper-catalyzed dehydrogenated methylsulfonylation of alkenes utilizing CH<sub>3</sub>SSO<sub>3</sub>Na in conjunction with hypervalent iodine reagents was successfully established. This method offers a practical avenue to obtain allyl methyl sulfones and alkenyl methyl sulfones by forming C-S bonds. Using the C-H bond oxidation sulfonylation strategy with alkenes and Bunte salts, we successfully synthesized a total of twenty two compounds, including four examples of deuterium-substituted molecules, and demonstrated one example of a scale-up reaction.
Authors
- Ge Wu (ORCID: https://orcid.org/0000-0001-8432-5272)
- Xiaoli Chen (ORCID: https://orcid.org/0000-0003-2550-542X)
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
Publication Details
- Journal
- BMC Chemistry
- Published
- 2025-02-22
- DOI
- https://doi.org/10.1186/s13065-025-01426-0
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- State Key Laboratory of Structural Chemistry