Enhanced exosome secretion regulated by microglial P2X7R in the medullary dorsal horn contributes to pulpitis-induced pain
This study highlights the regulatory role of microglial P2X7R in increased exosome secretion, indicating the potential utility of P2X7R as a promising target for pulpitis therapy. Our research highlights a new pulpitis mechanism in which exosomes enriched with IL-1β contribute to pulpitis-induced pain, suggesting the crucial roles of exosomes as pain biomarkers and harmful signaling molecules during pulpitis.
Authors
- Xiaoning Kang (ORCID: https://orcid.org/0000-0003-0394-6240)
- Lu Yang (ORCID: https://orcid.org/0000-0002-1883-9045)
- Mingjun Wang (ORCID: https://orcid.org/0000-0002-1020-3915)
- Fengjiao Yang
- Jing Zhang (ORCID: https://orcid.org/0009-0000-3057-3705)
- Xiaoke Wu
- Zhuo Yu (ORCID: https://orcid.org/0009-0007-8532-3747)
- Shukai Sun
- Jing Zhang (ORCID: https://orcid.org/0000-0002-7650-4702)
Institutions
- Air Force Medical University (CN)
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2025-02-22
- DOI
- https://doi.org/10.1186/s13578-025-01363-4
- Citations
- 3
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 3.35
Funders
- National Natural Science Foundation of China
- Key Research and Development Projects of Shaanxi Province