Azoospermia/Oligozoospermia and Prostate Cancer are Increased in Families of Women with Primary Ovarian Insufficiency
The data demonstrate excess familial clustering of severe spermatogenic impairment compared to matched population rates, along with higher prostate cancer risk in relatives of women with POI. These findings support a common genetic contribution to POI, spermatogenic impairment, and prostate cancer.
Authors
- Joshua John Horns (ORCID: https://orcid.org/0000-0002-0602-2900)
- Samantha Kodama
- James M. Hotaling (ORCID: https://orcid.org/0000-0002-4401-4565)
- Joemy M. Ramsay (ORCID: https://orcid.org/0000-0002-6057-5696)
- Lauren Elizabeth Verrilli (ORCID: https://orcid.org/0000-0001-7058-8303)
- Lisa Cannon‐Albright (ORCID: https://orcid.org/0000-0003-2602-3668)
- Kenneth I. Aston (ORCID: https://orcid.org/0000-0001-6459-2103)
- Erica Boiman Johnstone (ORCID: https://orcid.org/0000-0002-3382-3500)
- Corrine Kolka Welt (ORCID: https://orcid.org/0000-0002-8219-5504)
- Kristina Allen‐Brady (ORCID: https://orcid.org/0000-0001-9394-5211)
- Benjamin R Emery
Institutions
- Intermountain Healthcare (US)
- Cotton (United States) (US)
- University of Utah (US)
Publication Details
- Journal
- Journal of the Endocrine Society
- Published
- 2025-02-22
- DOI
- https://doi.org/10.1210/jendso/bvaf030
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Utah
- Huntsman Cancer Foundation
- Centers for Disease Control and Prevention
- Instituto Nacional do Câncer, Ministério da Saúde