Antitumor effects of BPCO on liver cancer cells
Esculetin is a coumarin compound with anticancer, antioxidant, and anti-inflammatory activities. In this study, we synthesized an esculetin derivative, 6,7-bis(Pentyloxy)-2H-Chromen-2-One (BPCO), through etherification. BPCO inhibited the proliferation of HepG2 cells in a dose- and time-dependent manner. It also inhibited cell migration, promoted apoptosis, and caused cell cycle arrest at the G1 phase. Additionally, BPCO downregulated the expression levels of Bcl-2 and Bcl-XL and upregulated the expression levels of Bax and Bak. This study shows that BPCO inhibits hepatocellular carcinoma cell proliferation and induces apoptosis, providing a basis for further study of BPCO as an antitumor agent.
Authors
- Shan-Bin Li
- Cheng-Qin Liang (ORCID: https://orcid.org/0000-0002-4611-6581)
- Jian Zou (ORCID: https://orcid.org/0009-0006-9624-6487)
- Kangzhi Li (ORCID: https://orcid.org/0000-0003-3329-2161)
- Tong-Shi-Yao Zhao
- Xian‐Li Zhou (ORCID: https://orcid.org/0000-0002-1690-0578)
- Zhen Ye (ORCID: https://orcid.org/0000-0002-0687-8901)
- Xi Yuan (ORCID: https://orcid.org/0000-0001-8731-216X)
- Lanzhen Huang (ORCID: https://orcid.org/0000-0002-9603-0858)
Institutions
- Guilin Medical University (CN)
- Guangxi Zhuang Autonomous Region Department of Education (CN)
Publication Details
- Journal
- Journal of Asian Natural Products Research
- Published
- 2025-02-22
- DOI
- https://doi.org/10.1080/10286020.2025.2467318
- Citations
- 3
- Primary Topic
- Eicosanoids and Hypertension Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 3.34
Funders
- Natural Science Foundation of Guangxi Zhuang Autonomous Region