Dataset of histone H3K4me2 modified genes in the liver of female Sprague-Dawley rats with chronic antipsychotic drugs of olanzapine or clozapine
Epigenetic histone modifications have been found to be associated with the development of metabolic disorders. However, the potential contribution of these modifications to metabolic disturbances induced by chronic treatment with second-generation antipsychotic drugs (SGAs) remains unclear. This dataset presents chromatin immunoprecipitation (ChIP) data on H3K4me methylation in hepatic tissue of rats treated with olanzapine or clozapine for 9 weeks for a comprehensive view of the effects of SGAs on H3K4me methylation in an animal model. It offers new insights into the epigenetic mechanisms underlying SGAs-induced metabolic side effects.
Authors
- Yueqing Su
- Chao Deng (ORCID: https://orcid.org/0000-0003-1147-5741)
- Jiamei Lian
Institutions
- Fujian Medical University (CN)
- University of Wollongong (AU)
- Fuzhou Maternity and Child Health Care Hospital (CN)
Publication Details
- Journal
- Data in Brief
- Published
- 2025-02-22
- DOI
- https://doi.org/10.1016/j.dib.2025.111425
- Citations
- 1
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- National Health and Medical Research Council
- Fujian Provincial Health Technology Project