The safety assessment of ustekinumab on psoriasis and psoriatic arthritis: A real-world analysis based on the FDA adverse event reporting system database
This study highlights a spectrum of UST-associated ADEs covering 25 SOCs in the treatment of patients with psoriasis and PsA, which emphasizes the need for vigilant clinical monitoring, particularly for infections, hepatobiliary disorders, and rare but high-signal events such as notalgia paraesthetica, chronic actinic dermatitis and pure testicular seminoma stage I. Clinicians should combine insights from both spontaneous and HCP reports and pay special attention to infections and reproductive system disorders.
Authors
- Jin Bu (ORCID: https://orcid.org/0000-0001-8555-0922)
- Xiangming Chen (ORCID: https://orcid.org/0000-0002-2571-3539)
- Erxia Shen (ORCID: https://orcid.org/0000-0003-1522-3138)
- Xiaojing Gao (ORCID: https://orcid.org/0000-0002-3094-1456)
- Jijun Huang (ORCID: https://orcid.org/0009-0004-9379-0263)
- Yue Liao (ORCID: https://orcid.org/0009-0003-9031-2373)
- Yanling Zheng (ORCID: https://orcid.org/0000-0002-8041-2843)
- Xiaomin Li (ORCID: https://orcid.org/0000-0001-8718-2780)
- Yu Zheng
- Jiamin Liu (ORCID: https://orcid.org/0009-0007-9802-5562)
- Rui-Lian Ding
- Yuyang Zhao (ORCID: https://orcid.org/0009-0009-7577-694X)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Chinese Academy of Medical Sciences Dermatology Hospital (CN)
- Qingdao Municipal Center for Disease Control and Prevention (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-02-22
- DOI
- https://doi.org/10.1016/j.intimp.2025.114339
- Citations
- 5
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 3.99