Risk of acute renal failure associated with combined use of SGLT2 inhibitors and potentially nephrotoxic drugs: an epidemiological surveillance study based on the FDA adverse event reporting system (FAERS)
This study confirms prior evidence of ARF associated with the combined use of SGLT2i with diuretics or NSAIDs and identifies new risks with proton pump inhibitors (PPIs), antigout medications, and anticoagulants. Male gender was a significant risk factor.
Authors
- Ling Huang
- Ting Yu (ORCID: https://orcid.org/0009-0005-5709-8306)
- Ruwen Cai (ORCID: https://orcid.org/0000-0003-0090-7262)
- Huimin Yu (ORCID: https://orcid.org/0000-0002-9258-5063)
- Shuqiao Cheng (ORCID: https://orcid.org/0000-0001-5053-0315)
- Mengyao Li (ORCID: https://orcid.org/0009-0006-1591-3760)
- Jing Yang Li
- Ying Wang (ORCID: https://orcid.org/0000-0003-2121-7025)
- Yingying Zhang (ORCID: https://orcid.org/0000-0001-8794-364X)
- Jian Xiao (ORCID: https://orcid.org/0000-0002-4039-306X)
Institutions
- Central South University (CN)
- Xiangya Hospital Central South University (CN)
- Dali University (CN)
Publication Details
- Journal
- Expert Opinion on Drug Safety
- Published
- 2025-02-22
- DOI
- https://doi.org/10.1080/14740338.2025.2471529
- Citations
- 3
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 3.88
Funders
- Natural Science Foundation of Hunan Province