Efficacy and safety of entrectinib in children with extracranial solid or central nervous system (CNS) tumours harbouring NTRK or ROS1 fusions
Integrated data from three trials confirm entrectinib induces rapid and durable responses in children with NTRK or ROS1 fusion-positive tumours. The increased duration of safety monitoring does not demonstrate new or cumulative toxicity. Registered clinical trials: STARTRK-NG: NCT02650401; TAPISTRY: NCT04589845; STARTRK-2: NCT02568267.
Authors
- Michela Casanova (ORCID: https://orcid.org/0000-0003-0368-7883)
- Bo Ci (ORCID: https://orcid.org/0000-0003-1721-8076)
- Jade Wulff
- Ellen M. Basu (ORCID: https://orcid.org/0000-0002-4555-220X)
- Quentin Campbell-Hewson (ORCID: https://orcid.org/0000-0003-1509-6925)
- Amy E. Armstrong (ORCID: https://orcid.org/0000-0002-7784-0476)
- Ami Vijay Desai (ORCID: https://orcid.org/0000-0001-9658-3156)
- Amar Gajjar (ORCID: https://orcid.org/0000-0001-5019-0699)
- Elizabeth Fox (ORCID: https://orcid.org/0000-0002-9998-5326)
- Nicolás André (ORCID: https://orcid.org/0000-0002-6786-4968)
- Giles W Robinson (ORCID: https://orcid.org/0000-0001-7441-9486)
- Clare Devlin
- Huanmin Wang (ORCID: https://orcid.org/0000-0001-8338-0325)
- Alison K. Cardenas
- Cornelis Martinus van Tilburg (ORCID: https://orcid.org/0000-0001-5274-910X)
- Georgina Meneses‐Lorente (ORCID: https://orcid.org/0000-0001-8961-0902)
- Katherine E. Hutchinson (ORCID: https://orcid.org/0000-0002-4660-3523)
- Carolina Ryklansky
- Yeming Wu
- Aditi Bagchi (ORCID: https://orcid.org/0000-0001-5466-7685)
Institutions
- St. Jude Children's Research Hospital (US)
- Memorial Sloan Kettering Cancer Center (US)
- Inserm (FR)
- German Cancer Research Center (DE)
- Washington University in St. Louis (US)
- Aix-Marseille Université (FR)
- Heidelberg University (DE)
- Royal Victoria Infirmary (GB)
- XinHua Hospital (CN)
- University Hospital Heidelberg (DE)
- Genesys (United States) (US)
- University of Chicago Medical Center (US)
- Align Technology (United States) (US)
- Gene Therapy Laboratory (FR)
- Roche (United Kingdom) (GB)
- Yahoo (United States) (US)
- Beijing Children’s Hospital (CN)
- Centre de Recherche en Cancérologie de Marseille (FR)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Hôpital de la Timone (FR)
Publication Details
- Journal
- European Journal of Cancer
- Published
- 2025-02-22
- DOI
- https://doi.org/10.1016/j.ejca.2025.115308
- Citations
- 8
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 13.00
Funders
- Roche
- F. Hoffmann-La Roche
- St. Jude Children's Research Hospital
- Children’s Oncology Group