Paraneoplastic Pemphigus in a Patient With Pheochromocytoma: A Report of a Rare Case

This report details a rare case of paraneoplastic pemphigus (PNP) associated with pheochromocytoma. The patient presented with prominent dermatological manifestations, including erythema, vesicles, and erosions. During hospitalization, diagnostic imaging revealed a retroperitoneal mass, which was subsequently surgically removed. A comprehensive diagnostic workup, including CT, MRI, histopathological analysis, and direct immunofluorescence examination, was conducted. Postoperative management combined with pharmacological intervention led to significant clinical improvement. This case highlights the critical importance of considering PNP in the differential diagnosis of pheochromocytoma, particularly in patients presenting with complex autoimmune manifestations. The findings underscore the necessity for early diagnosis and prompt therapeutic intervention in such cases. Additionally, this report emphasizes the need for further investigation into the clinical spectrum, genetic associations, and underlying mechanisms of this rare disease association to enhance diagnostic accuracy and therapeutic outcomes.