Machine learning prediction of tau‐PET in Alzheimer's disease using plasma, MRI, and clinical data
Accessible variables showed potential in estimating tau tangle load and distribution. Plasma phosphorylated tau-217 (p-tau217) and magnetic resonance imaging (MRI) were the best predictors of different tau-PET (positron emission tomography) composites. Machine learning models demonstrated high generalizability across AD cohorts.
Authors
- Nicholas James Ashton (ORCID: https://orcid.org/0000-0002-3579-8804)
- Alexa Pichet Binette (ORCID: https://orcid.org/0000-0001-5218-3337)
- Richard A. I. Bethlehem (ORCID: https://orcid.org/0000-0002-0714-0685)
- Renaud La Joie (ORCID: https://orcid.org/0000-0003-2581-8100)
- Sebastian Palmqvist (ORCID: https://orcid.org/0000-0002-9267-1930)
- Rik Ossenkoppele (ORCID: https://orcid.org/0000-0003-1584-7477)
- Erik Stomrud (ORCID: https://orcid.org/0000-0002-0841-5580)
- Olof T. Strandberg
- Ruben Smith (ORCID: https://orcid.org/0000-0001-7147-0112)
- Niklas Mattsson (ORCID: https://orcid.org/0000-0002-8885-7724)
- Oskar Hansson (ORCID: https://orcid.org/0000-0001-8467-7286)
- Gil Dan Rabinovici (ORCID: https://orcid.org/0000-0002-3626-4265)
- Jakob Seidlitz (ORCID: https://orcid.org/0000-0002-8164-7476)
- Kalle Åström (ORCID: https://orcid.org/0000-0002-8689-7810)
- Shorena Janelidze (ORCID: https://orcid.org/0000-0003-2869-8378)
- Jacob W. Vogel (ORCID: https://orcid.org/0000-0001-6394-9940)
- Ida Arvidsson (ORCID: https://orcid.org/0009-0007-6065-8639)
- Linda Karlsson (ORCID: https://orcid.org/0000-0002-0630-772X)
- Henrik Zetterberg
- Kaj Blennow
Institutions
- University of Science and Technology of China (CN)
- Statistics Sweden (SE)
- Children's Hospital of Philadelphia (US)
- University of California, San Francisco (US)
- King's College London (GB)
- Lund University (SE)
- University of Cambridge (GB)
- Science for Life Laboratory (SE)
- Hong Kong Science and Technology Parks Corporation (HK)
- Sahlgrenska University Hospital (SE)
- University of California System (US)
- Sorbonne Université (FR)
- Amsterdam Neuroscience (NL)
- Pitié-Salpêtrière Hospital (FR)
- Translational Therapeutics (United States) (US)
- UK Dementia Research Institute (GB)
- Skåne University Hospital (SE)
- National Hospital for Neurology and Neurosurgery (GB)
- Lifespan (US)
- Amsterdam University Medical Centers (NL)
- Institut du Cerveau (FR)
- University College London (GB)
- University of Pennsylvania (US)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/alz.14600
- Citations
- 20
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 29.42
Funders
- Alzheimer's Association
- EU Joint Programme – Neurodegenerative Disease Research
- Hjärnfonden
- Knut och Alice Wallenbergs Stiftelse
- Vetenskapsrådet
- Alzheimerfonden
- Science for Life Laboratory
- Skånes universitetssjukhus
- Parkinsonfonden
- Horizon 2020 Framework Programme
- National Institute on Aging
- H2020 European Research Council