Alcohol consumption and childhood trauma impact serum immunoglobulin levels in patients with alcohol use disorder
Heavy alcohol drinking is associated with elevated IgA levels, which may be a potential risk factor for alcohol-associated liver disease. On the other hand, childhood trauma's association with decreased IgG levels may be indicative of broader immune dysfunction. Taken together, changes in immunoglobulins may be valuable markers linking alcohol consumption and childhood trauma to immune health and disease progression.
Authors
- Nancy Diazgranados (ORCID: https://orcid.org/0000-0002-7415-8455)
- Kelly M. Abshire
- Lorenzo Leggio (ORCID: https://orcid.org/0000-0001-7284-8754)
- Melanie L. Schwandt (ORCID: https://orcid.org/0000-0002-8355-4900)
- Mehdi Farokhnia (ORCID: https://orcid.org/0000-0003-0902-4212)
Institutions
- National Institute on Drug Abuse (US)
- Johns Hopkins University (US)
- Georgetown University (US)
- Brown University (US)
- Johns Hopkins Medicine (US)
- Georgetown University Medical Center (US)
- National Institute on Alcohol Abuse and Alcoholism (US)
Publication Details
- Journal
- Alcohol Clinical and Experimental Research
- Published
- 2025-02-22
- DOI
- https://doi.org/10.1111/acer.15537
- Primary Topic
- Alcohol Consumption and Health Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health