Tailored Fibrils Approach via Ag(I).Peptidomimetic-Based Interface Design: Efficient Encapsulation of Diverse Active Pharmaceutical Ingredients in Wastewater Remediation during Effluent Treatment Plant (ETP) Processing

Pharmaceutical pollution in wastewater poses significant environmental and public health concerns worldwide. Chloramphenicol (CP), an antibiotic widely used in medical and veterinary applications, is among the active pharmaceutical ingredients (APIs) frequently detected in aquatic environments. This study explored the encapsulation of chloramphenicol API in contaminated wastewater using rationally designed fibrations based on the silver metal ion-directed self-assembly of fibrillator-type self-assembling ligand (<b>ANS-3</b>). We further investigated the removal of various commonly prescribed drugs, including antibiotics such as β-lactam (amoxicillin), fluoroquinolone (ciprofloxacin), aminoglycoside (neomycin), and tetracycline; antiparasitic agents with antiprotozoal properties (praziquantel and metronidazole); nonsteroidal anti-inflammatory drugs (NSAIDs) such as phenylbutazone and ketoprofen; the vasodilator isoxsuprine; amphiphilic antidepressants (amitriptyline); and the antiviral drug amantadine. The findings validated the crucial influence of polar multifunctionality and structural complexity in enhancing interactions with <b>Ag</b>.<b>ANS-3</b> matrix, emphasizing its potential for efficient drug sequestration. First, picolinic acid (PA) and phenylalanine (F) were evaluated for their ability to form fibrillar structures, and their morphological characterization revealed well-defined fibrillar networks with varying degrees of porosity and interconnectivity. Then, the strategic inclusion of leucine in synthesizing <b>ANS-3</b> facilitated the formation of robust fibrillar networks, employing its hydrophobic interactions to drive the self-assembly process. Finally, the encapsulation of APIs was evaluated using Ag(I) metal ion-driven <b>ANS-3</b> based self-assembled nanofibrous material. This research contributes to the development of innovative physicochemical wastewater treatment strategies for environmental remediation and validates the importance of rational design in encapsulation-based wastewater remediation technologies.