Major Adverse Cardiovascular Events Related to JAK Inhibitors: A Disproportionality Analysis Using the WHO Global Individual Case Safety Database
Compared with anti-TNFα, JAKis were more associated with MACE, especially stroke, and with a shorter time to onset. These data support the hypothesis of a different cardiovascular reporting frequency between JAKis and anti-TNFα. In patients with identified cardiovascular risk, anti-TNFα should be preferred to JAKis until more definitive results are available.
Authors
- Annalisa Capuano (ORCID: https://orcid.org/0000-0002-8653-2408)
- Francesco Salvo (ORCID: https://orcid.org/0000-0003-3210-7171)
- Christophe Richez (ORCID: https://orcid.org/0000-0002-3029-8739)
- Allison Singier (ORCID: https://orcid.org/0000-0003-3151-6299)
- Annamaria Mascolo (ORCID: https://orcid.org/0000-0003-2554-0065)
- Cristina Scavone (ORCID: https://orcid.org/0000-0002-9216-922X)
- Raffaella Di Napoli (ORCID: https://orcid.org/0009-0009-4497-3836)
- Maxime Demorgues
Institutions
- Centre National de la Recherche Scientifique (FR)
- Université de Bordeaux (FR)
- Inserm (FR)
- University of Campania "Luigi Vanvitelli" (IT)
- Centre Hospitalier Universitaire de Bordeaux (FR)
- Bordeaux Population Health (FR)
- Immunology from Concept and Experiments to Translation (FR)
- Hôpital Pellegrin (FR)
- University of Campania "Luigi Vanvitelli" (IT)
- Link Campus University (IT)
Publication Details
- Journal
- Drug Safety
- Published
- 2025-03-23
- DOI
- https://doi.org/10.1007/s40264-025-01535-8
- Citations
- 7
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 7.32
Funders
- Università degli Studi della Campania Luigi Vanvitelli