BIOCHEMICAL ROLE OF MAJOR MINERALS IN PREECLAMPSIA

Background - Preeclampsia is pregnancy-specific, multi-systemic syndrome of widespread endothelial malfunction and vasospasm developing after 20 weeks of gestation, defined by hypertension(BP>140/90 mm Hg), fluid retention and proteinuria. Imbalances in serum sodium and potassium causes vasoconstriction and hypertension in PE. Hypocalcemia stimulates parathyroid hormone, causing vasoconstriction. Magnesium regulates blood pressure by monitoring vascular tone and structure. Material And Methods- Analytical cross-sectional study conducted at biochemistry department IGGMC Nagpur, includes 150 pregnancies. Serum Electrolytes, Magnesium, Calcium level were estimated on auto analyzer and compared between two groups. students t –test was used to see the level of significance( P < 0.01). Result- Serum sodium(142.17±5.66 mmol/L and 136.13±4.17 mmol/L), potassium(3.45 ± 0.54 mmol/L and 3.98±0.36 mmol/L), Magnesium(1.530±0.299 and 1.742±0.226) and calcium(7.9±0.4 and 9.7±0.7) observed in preeclamptic and normotensive respectively. (p < 0.05) . Conclusions - Estimation of serum electrolytes, calcium and during pregnancy could help in early detection and prompt treatment of preeclampsia.