Development and In vitro Evalution of Buccoadhesive tablets of Propranolol

Buccal tablets of propranolol were prepared by direct compression method using different hydrophilic polymers such as hydroxypropyl methylcellulose, sodium carboxy methylcellulose and Carbopol. All the prepared formulations showed satisfactory mass uniformity, thickness and favourable drug content. The friability of all the formulation was below 1%, which is an indication of good mechanical resistance of tablets. Among all the formulations, F4 showed maximum swelling index and in vitro release. Drug release mechanism was determined by plotting release data to Higuchi and Korsmeyer-Peppas model. All the formulations are best fitted to Higuchi model and according to this model the drug releases from theses tablets may be controlled by diffusion. The surface pH of all formulations was found to be almost in neutral pH and no mucosal irritation was expected. The accelerated stability studies indicated that, the selected formulation (F4) showed almost same drug content, mass uniformity and residence time. No colour change or no changes in texture were observed when tablets were tested in simulated saliva solution (pH 6.8).