Sequential 90Y Selective Internal Radiation Therapy (SIRT) and Stereotactic Body Radiation Therapy (SBRT) using 90Y PET-based Absorbed Dose Maps: Interim Analysis of a Phase 1 Study
Interim analysis found that liver toxicity from <sup>90</sup>Y SIRT followed by SBRT was below the early stopping threshold, and continuation of the study to complete recruitment of 30 evaluable patients was recommended.
Authors
- Jared A. Christensen (ORCID: https://orcid.org/0009-0008-3404-5238)
- Daniel Polan (ORCID: https://orcid.org/0000-0002-8182-8832)
- Hassan Anbari (ORCID: https://orcid.org/0009-0002-9276-3357)
- Kellen Fitzpatrick
- Justin Mikell (ORCID: https://orcid.org/0000-0003-0679-7199)
- Theodore S. Lawrence (ORCID: https://orcid.org/0000-0002-4186-8821)
- Molly E Roseland (ORCID: https://orcid.org/0000-0002-5885-1487)
- Matthew J. Schipper (ORCID: https://orcid.org/0000-0001-6728-4720)
- Yuni K. Dewaraja (ORCID: https://orcid.org/0000-0002-3920-6925)
- Joseph R. Evans (ORCID: https://orcid.org/0000-0002-1342-270X)
- Madhava Aryal (ORCID: https://orcid.org/0000-0003-3938-1843)
- Joseph J. Gemmete (ORCID: https://orcid.org/0000-0003-2760-3613)
- Kyle Clifford Cuneo (ORCID: https://orcid.org/0000-0002-8264-6483)
- Daniel T. Chang (ORCID: https://orcid.org/0000-0003-2760-1554)
- Mamadou L. Sanogo (ORCID: https://orcid.org/0000-0001-8535-4251)
- Baljendra S. Kapoor (ORCID: https://orcid.org/0009-0001-2647-9596)
- Yue Cao (ORCID: https://orcid.org/0000-0002-2356-4031)
Institutions
- Washington University in St. Louis (US)
- University of Michigan (US)
Publication Details
- Journal
- Advances in Radiation Oncology
- Published
- 2025-02-22
- DOI
- https://doi.org/10.1016/j.adro.2025.101743
- Citations
- 3
- Primary Topic
- Advanced Radiotherapy Techniques
- Type
- article
- Field-Weighted Citation Impact
- 5.65
Funders
- National Institutes of Health
- National Cancer Institute
- National Institute of Biomedical Imaging and Bioengineering