Spread of the Fosfomycin resistance fosA3 gene via the IS26 mobile element between plasmids and the chromosome of carbapenem-resistant Escherichia coli in China
This study revealed fosA3 in CREC strains was associated with IS26 and spreads fosfomycin resistance through horizontal transfer, occurring both on chromosomes and plasmids. The first fosA3-carrying cointegrate plasmid pHN7A8-IncX3-type in E. coli isolates was reported, highlighting a new route of fosfomycin resistance spread. Additionally, notable diversity of ST among fosA3-carrying E. coli strains highlights complexity of fosfomycin resistance dissemination and the importance of surveillance and control measures.
Authors
- Chuanxin Yang (ORCID: https://orcid.org/0000-0003-3829-2961)
- Jiayao Yao
- Yuexing Tu (ORCID: https://orcid.org/0000-0003-3073-8746)
- Xiaofan Zhang (ORCID: https://orcid.org/0000-0003-1025-164X)
- Huan Wang (ORCID: https://orcid.org/0000-0003-1115-143X)
- Lijuan Liu (ORCID: https://orcid.org/0000-0001-8068-8498)
- Xi Li (ORCID: https://orcid.org/0000-0002-5538-9688)
- Ying Zhang (ORCID: https://orcid.org/0000-0001-9900-7568)
- Longjie Zhou
Institutions
- Zhejiang Provincial People's Hospital (CN)
- Shanghai Sixth People's Hospital (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Journal of Global Antimicrobial Resistance
- Published
- 2025-02-22
- DOI
- https://doi.org/10.1016/j.jgar.2025.02.011
- Citations
- 3
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 1.77
Funders
- National Natural Science Foundation of China