Integration of single-cell and bulk RNA sequencing to identify a distinct tumor stem cells and construct a novel prognostic signature for evaluating prognosis and immunotherapy in LUAD
This study demonstrates the TSCMS model's prognostic value in LUAD, reveals insights into immune infiltration and therapeutic response, and identifies TAF10 as a potential therapeutic target.
Authors
- Fugui Li (ORCID: https://orcid.org/0000-0003-1768-2696)
- Fengyun Zhao (ORCID: https://orcid.org/0000-0003-2266-066X)
- Mingfang Ji (ORCID: https://orcid.org/0000-0003-4727-2858)
- Mengting Chen (ORCID: https://orcid.org/0000-0002-7656-895X)
- Tianjiao Wu
Institutions
- Guangdong Medical College (CN)
- South China Normal University (CN)
- Zhongshan People's Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-02-22
- DOI
- https://doi.org/10.1186/s12967-025-06243-6
- Citations
- 10
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 10.45