Irf7 aggravates prostatitis by promoting Hif-1α-mediated glycolysis to facilitate M1 polarization
Our findings indicate that Irf7 can contribute to the development and progression of CP/CPPS by promoting glycolysis, which can enhance both M1 polarization as well as interstitial fibrosis in the prostate. This process was found to be mediated by the upregulation of Hif-1α transcription, presenting new potential therapeutic targets for managing CP/CPPS.
Authors
- Weikang Wu (ORCID: https://orcid.org/0000-0002-5821-2474)
- Junyang Yue (ORCID: https://orcid.org/0000-0002-5299-0160)
- Wei Peng (ORCID: https://orcid.org/0000-0002-5780-2157)
- Huihui Wang (ORCID: https://orcid.org/0000-0002-4375-0480)
- Jing Chen
- Meng Tong (ORCID: https://orcid.org/0000-0003-4832-2490)
- Chaozhao Liang (ORCID: https://orcid.org/0000-0002-4551-9792)
- Cong Huang (ORCID: https://orcid.org/0009-0002-8307-4517)
- Wanqing Liu
- Cheng Yang
- Yi Zhang (ORCID: https://orcid.org/0000-0001-6223-4724)
Institutions
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Cellular and Molecular Life Sciences
- Published
- 2025-02-22
- DOI
- https://doi.org/10.1007/s00018-025-05608-w
- Citations
- 12
- Primary Topic
- Immune responses and vaccinations
- Type
- article
- Field-Weighted Citation Impact
- 9.57
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Anhui Province