New LFA-1 inhibitor Orientin reduces angiotensin II-induced vascular remodeling
Here, we identified Orientin as a small molecule inhibitor of LFA-1 with anti-vascular remodeling function. These findings not only suggest that Orientin is a promising compound for the clinical treatment of vascular injury and hypertension, but also provide strategies for the treatment of cardiovascular diseases.
Authors
- Xiangbo An
- Yinong Jiang (ORCID: https://orcid.org/0000-0002-9080-7523)
- Rui Wang (ORCID: https://orcid.org/0000-0003-1723-4746)
- Yitong Wang (ORCID: https://orcid.org/0000-0003-0490-2186)
- Ying Zhang (ORCID: https://orcid.org/0000-0003-1537-4526)
Institutions
- Dalian Medical University (CN)
- Peking University (CN)
- Beijing Anzhen Hospital (CN)
- Peking University First Hospital (CN)
- First Affiliated Hospital of Dalian Medical University (CN)
Publication Details
- Journal
- European Journal of Pharmacology
- Published
- 2025-02-22
- DOI
- https://doi.org/10.1016/j.ejphar.2025.177426
- Primary Topic
- Antiplatelet Therapy and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China