Metrnl/C‐KIT Axis Attenuates Early Brain Injury Following Subarachnoid Hemorrhage by Inhibiting Neuronal Ferroptosis
Our study demonstrated that r-Metrnl reduced neuronal ferroptosis and improved neurological outcomes after SAH by modulating the C-KIT/AMPK/Nrf2 signaling pathway.
Authors
- Qin Yu (ORCID: https://orcid.org/0000-0001-6379-9444)
- Yunxing Cao
- Jianhe Yue
- Luyi Huang (ORCID: https://orcid.org/0000-0002-0377-877X)
- Qiuguang He (ORCID: https://orcid.org/0000-0001-8680-7670)
- Yihao Tao
- You Zhou (ORCID: https://orcid.org/0000-0002-7081-921X)
- Ye Yuan (ORCID: https://orcid.org/0009-0005-3886-3527)
- Hao Zhang (ORCID: https://orcid.org/0000-0002-0049-1220)
- Feng Wang (ORCID: https://orcid.org/0000-0002-7547-3115)
- Lei Wu (ORCID: https://orcid.org/0000-0001-9762-0684)
- Xu Luo
- Jiani Li (ORCID: https://orcid.org/0009-0002-5563-4505)
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Guangdong Provincial People's Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1111/cns.70286
- Citations
- 7
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 10.63
Funders
- Chongqing Postdoctoral Science Foundation
- National Natural Science Foundation of China