Lactobacillus rhamnosus GG in Paediatric Acute Diarrhoea: A Clinical Perspective and Systematic Review of Clinical Studies Published in the Last Decade

Gut dysbiosis is one of the risk factors to cause acute diarrhoea in children. Lactobacillus rhamnosus GG (L. rhamnosus GG) is one of the most studied probiotic strains and its efficacy in acute diarrhoea is validated in various clinical studies. The current systematic review aimed to evaluate the efficacy of L. rhamnosus GG in paediatric acute diarrhoea by using the clinical studies published in the last decade (till September 2023). Articles were retrieved from five online databases and screened as per the pre-designed protocol. The quality of the studies that qualified was assessed using the Physiotherapy Evidence Database (PEDro) scale. The studies were critically reviewed for the efficacy of L. rhamnosus GG in various parameters related to paediatric acute diarrhoea conditions. After screening 1758 articles for eligibility, six studies were considered in the current study. Every study that was included was of a moderate-to-good quality. L. rhamnosus GG supplementation in combination with standard therapy shows better improvement in diarrhoea duration, stool consistency, stool frequency, and duration of hospital stay as compared to standard therapy alone supplementation. The study’s findings are consistent with the results of previous studies and suggest that the supplementation of Lactobacillus rhamnosus GG is an effective adjunct therapy in paediatric acute diarrhoea conditions. How to cite this article:Kheni D B, Sureja V P, Deshpande S S, Dubey V P, Kansagra J J. Lactobacillus rhamnosus GG in Paediatric Acute Diarrhoea: A Clinical Perspective and Systematic Review of Clinical Studies Published in the Last Decade. Chettinad Health City Med J. 2024;13(4):135-145. DOI: https://doi.org/10.24321/2278.2044.202470