OC-STAMP is a potential biomarker and therapeutic target for Silicosis: an exploratory investigation
Overall, OC-STAMP induces ferroptosis and exacerbates fibrosis in Silicosis. OC-STAMP siRNA and Fer-1 mitigate abnormal collagen deposition and delay the progression of Silicosis. Collectively, these findings highlight the potential of OC-STAMP as a novel biomarker for diagnosing and treating Silicosis.
Authors
- Yuebin Ke (ORCID: https://orcid.org/0000-0003-1104-1898)
- Yimin Shi (ORCID: https://orcid.org/0000-0002-9779-5967)
- Xue Yi (ORCID: https://orcid.org/0000-0002-3657-1214)
- Chunhong Xie
- Bingyu Zhang (ORCID: https://orcid.org/0000-0003-2539-4571)
- Jing Wu
- Wei Du (ORCID: https://orcid.org/0000-0002-8333-0069)
Institutions
- Fujian Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1186/s12967-024-05981-3
- Citations
- 7
- Primary Topic
- Occupational and environmental lung diseases
- Type
- article
- Field-Weighted Citation Impact
- 10.63