CALCINEURIN CRISIS: A RARE CASE SERIES OF PANCREATITIS AND AKI INDUCED BY CALCINEURIN INHIBITORS.

Drug-induced pancreatitis is an uncommon and under-reported cause of acute pancreatitis, with limited evidence supporting the association of many suspected medications. This case series presents two rare instances of acute pancreatitis: one induced by Tacrolimus and the other by Cyclosporine, highlighting these medications as infrequent and poorly documented contributors to this condition. We report two cases of acute pancreatitis linked to immunosuppressive therapy. A 57-year-old female developed pancreatitis one month after starting Tacrolimus for steroid-resistant FSGS, and a 41-year-old male on Cyclosporine for 15 days for aplastic anemia presented with similar features. Clinical, laboratory, and imaging findings confirmed the diagnosis in both cases, with Tacrolimus and Cyclosporine identified as the likely causes after excluding other etiologies. These cases highlight the need for clinicians to consider Tacrolimus and Cyclosporine as potential triggers of acute pancreatitis in patients receiving these treatments and in managing patients with acute pancreatitis.