Comprehensive implementations of multiple imputation using retrieved dropouts for continuous endpoints
We have presented comprehensive implementations of the MIRD approach for continuous endpoints in a longitudinal setting that fully fit within the strategy of treatment policy. The proposed new class based on all observed data of RDs is proved to be as powerful as the established MIRD approach based on last on-treatment visit in most scenarios. The one-step MCMC approach is more powerful than the established MIRD approach in certain scenarios. Since the new class involves less programming derivation of additional flags, it's anticipated to be more easily implemented in clinical trial reporting.
Authors
- Shuai Wang (ORCID: https://orcid.org/0000-0002-0984-5435)
- Pamela F. Schwartz
- James P. Mancuso (ORCID: https://orcid.org/0000-0002-5722-1360)
Institutions
- Pfizer (United States) (US)
Publication Details
- Journal
- BMC Medical Research Methodology
- Published
- 2025-02-21
- DOI
- https://doi.org/10.1186/s12874-025-02494-5
- Citations
- 2
- Primary Topic
- Statistical Methods in Clinical Trials
- Type
- article
- Field-Weighted Citation Impact
- 5.26