Distribution of EGFR and KRAS Mutations in Patients with Surgically Resected Non-Small Cell Lung Cancer from Southern Italy: Real-Life Data from a Single Institution and Literature Review
Our findings improve the understanding of lung cancer genetics in a small and homogeneous area of Southern Italy and guide future research. The <i>EGFR</i> and <i>KRAS</i> mutations in NSCLC resected patients from Southern Italy showed a global similar incidence compared to other recently described Italian cohorts of advanced and early-stage NSCLC, with a higher frequency of exon19 <i>EGFR</i> deletions. No prognostic impact was observed for both <i>EGFR</i> and <i>KRAS</i> status, but additional investigations on a larger cohort are needed.
Authors
- Fabiola Fiordelisi
- Flavia Centra (ORCID: https://orcid.org/0000-0003-1945-6975)
- Paola Parente (ORCID: https://orcid.org/0000-0003-0591-6723)
- Marco Donatello Delcuratolo (ORCID: https://orcid.org/0000-0003-3151-9166)
- Lucia Anna Muscarella (ORCID: https://orcid.org/0000-0002-1866-8151)
- Paolo Graziano (ORCID: https://orcid.org/0000-0001-7066-7896)
- Federico Pio Fabrizio (ORCID: https://orcid.org/0000-0002-9122-1348)
- Mario Mastroianno (ORCID: https://orcid.org/0000-0003-3218-1646)
- Concetta Martina Di Micco
- Michele Piazzolla (ORCID: https://orcid.org/0000-0002-3609-1587)
- Antonella Centonza (ORCID: https://orcid.org/0000-0002-6735-9777)
- Francesco Delli Muti
- Gianmaria Ferretti
Institutions
- Casa Sollievo della Sofferenza (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Cancers
- Published
- 2025-02-21
- DOI
- https://doi.org/10.3390/cancers17050730
- Citations
- 2
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- Ministero della Salute